hla-dpb۱ variant effect on hepatitis b virus clearance and liver cirrhosis development among southwest chinese population

conclusions variant at rs9277534 could affect both the spontaneous clearance of hbv infection and progression from asymptomatic hbv carriers to hbv-related liver cirrhosis in southwest han chinese population. results there was a significantly higher proportion of the rs9277534 minor allele a in hbv spontaneous clearance control than that in hbv persistent infection group (or = 0.58, 95%ci = 0.46-0.73, p < 0.0001). genotypic analysis showed that ga and aa genotypes were associated with hbv spontaneous clearance (ga: or = 0.56, 95%ci = 0.40-0.79, p = 0.019; aa: or = 0.24, 95%ci = 0.14-0.44, p < 0.0001). a significant difference was found between asc and lc groups in the distribution of aa genotype (or = 9.32, 95%ci = 1.293-67.14, p = 0.027). materials and methods snapshot assay was used to investigate the association of rs9277534 polymorphism in 342 patients with persistent hbv infection and 342 age- and gender-matched hbv spontaneous clearance controls. patients were categorized into asymptomatic hbv carriers (asc, n = 104), chronic hepatitis b (chb, n = 116), and liver cirrhosis (lc, n = 122) subgroups. objectives we aimed to evaluate possible association between hla-dpb1 rs9277534 polymorphism and different clinical complications of hepatitis b virus (hbv) infection. background previous studies have shown that genetic variants in hla-dp genes affect disease progression in hepatitis b virus (hbv) infection.